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About Celia A. Schiffer

Celia A. Schiffer, Ph.D., is a Professor in the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School. She conceptualized an interdisciplinary approach to avoid drug resistance and co-founded the Institute for Drug Resistance. Dr. Schiffer has a BA in physics from the University of Chicago, Ph.D. in biophysics from University of California, San Francisco, with postdoctoral training at the ETH in Zurich, Switzerland and Genentech, Inc. She has published 70 peer reviewed journal articles, using a combination of experimental and computational biophysical techniques to obtain key biological insights. Her laboratory primarily studies the molecular basis for drug resistance in HIV and more recently Hepatitis C. In addition to three NIH R01’s, she leads a renewed $8.6 million NIH program project grant: “Targeting Ensembles of Drug Resistant HIV Proteases.” Through her research, she has developed a new paradigm for avoiding drug resistance that likely translates to other diseases. This new paradigm is the basis for the design of novel picomolar HIV-1 protease inhibitors that are more potent in viral cultures of wild-type and resistant viruses than the leading HIV-1 protease inhibitor Darunavir. These novel inhibitors strongly support the premise: that by putting drug resistance first in development of drug design strategies, inhibitors can be developed that are more robust against drug resistance.

Positions

Present Director, Center for AIDS Research (CFAR), University of Massachusetts Medical School
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Present Founder / Co-Director, Institute for Drug Resistance, University of Massachusetts Medical School
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Present Professor, University of Massachusetts Medical School Department of Biochemistry and Molecular Pharmacology
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Curriculum Vitae




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Honors and Awards

  • Outstanding Mentoring to Women Faculty Award, UMass Medical School (2010)
  • Women in Science and Health Achievements Award, UMass Medical School (2005)
  • Best Poster, XI International HIV Drug Resistance Workshop, Seville, Spain (2002)
  • Chancellor’s Award for Excellence in Mentoring, UMass Medical School (2016)
  • Mentoring Award for excellence in mentoring of STEM trainees, Massachusetts Society for Medical Research (2016)


Contact Information

Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
364 Plantation Street, Rm 923
Worcester MA, 01605-2324
Phone: (508) 856-8008

Email:



Articles (155)