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Article
Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6.
GSBS Student Publications
  • Rajintha M. Bandaranayake, University of Massachusetts Medical School
  • Moses Prabu-Jeyabalan, University of Massachusetts Medical School
  • Junko Kakizawa, National Institute of Infectious Diseases, Tokyo, Japan
  • Wataru Sugiura, National Institute of Infectious Diseases, Tokyo, Japan
  • Celia A. Schiffer, University of Massachusetts Medical School
Publication Date
2008-7-1
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Document Type
Article
Abstract

The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease compared to the clade B protease structure.

DOI of Published Version
10.1128/JVI.00018-08
Source
J Virol. 2008 Jul;82(13):6762-6. Link to article on publisher's website
Related Resources
Link to article in PubMed
PubMed ID
18434392
Citation Information
Rajintha M. Bandaranayake, Moses Prabu-Jeyabalan, Junko Kakizawa, Wataru Sugiura, et al.. "Structural analysis of human immunodeficiency virus type 1 CRF01_AE protease in complex with the substrate p1-p6." Vol. 82 Iss. 13 (2008) ISSN: 1098-5514
Available at: http://0-works.bepress.com.library.simmons.edu/celia_schiffer/2/