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Regulation of the Drosophila Imd pathway by signaling amyloids
Open Access Articles
  • Anni Kleino, Aarhus University
  • Neal S. Silverman, University of Massachusetts Medical School
UMMS Affiliation
Division of Infectious Diseases and Immunology, Department of Medicine
Publication Date
Document Type

Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.

  • Drosophila immunity,
  • Functional amyloid,
  • Imd signaling
Rights and Permissions
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
DOI of Published Version

Insect Biochem Mol Biol. 2019 May;108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9. Link to article on publisher's site

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Link to Article in PubMed

PubMed ID
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Citation Information
Anni Kleino and Neal S. Silverman. "Regulation of the Drosophila Imd pathway by signaling amyloids" Vol. 108 (2019) ISSN: 0965-1748 (Linking)
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