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Article
Regulation of the Drosophila Imd pathway by signaling amyloids
Open Access Articles
  • Anni Kleino, Aarhus University
  • Neal S. Silverman, University of Massachusetts Medical School
UMMS Affiliation
Division of Infectious Diseases and Immunology, Department of Medicine
Publication Date
2019-5-1
Document Type
Article
Abstract

Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-kappaB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.

Keywords
  • Drosophila immunity,
  • Functional amyloid,
  • Imd signaling
Rights and Permissions
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
DOI of Published Version
10.1016/j.ibmb.2019.03.003
Source

Insect Biochem Mol Biol. 2019 May;108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID
30857831
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Citation Information
Anni Kleino and Neal S. Silverman. "Regulation of the Drosophila Imd pathway by signaling amyloids" Vol. 108 (2019) ISSN: 0965-1748 (Linking)
Available at: http://0-works.bepress.com.library.simmons.edu/neal_silverman/79/