Skip to main content
Article
New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities
Faculty of Science - Papers (Archive)
  • Timothy P Boyle, University of Wollongong
  • John B Bremner, University of Wollongong
  • Jonathan Coates, Avexa
  • John Deadman, Avexa
  • Paul A Keller, University of Wollongong
  • Stephen G Pyne, University of Wollongong
  • David I Rhodes, Avexa Ltd
RIS ID
25502
Publication Date
1-1-2008
Publication Details

This article was originally published as Boyle, TP, Bremner, JB, Coates, J, Deadman, J, Keller, PA, Pyne, SG & Rhodes, DI, New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities, Tetrahedron, 64(49), 2008, 11270-11290. Original journal article available here

Abstract
As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as potential novel anti-bacterial agents, we explored the synthesis of simple tyrosine-based systems. These were prepared via key intermediates containing internal allylglycine and allyltyrosine residues for subsequent ring closing metathesis reactions. Although the resulting anti-bacterial activity against Staphylococcus aureus was modest, this represents a novel and simple route to this class of compounds. One intermediate acyclic dipeptide precursor showed good activity against S. aureus with an MIC of 7.8 µg/mL.
Citation Information
Timothy P Boyle, John B Bremner, Jonathan Coates, John Deadman, et al.. "New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities" (2008)
Available at: http://0-works.bepress.com.library.simmons.edu/pkeller/13/