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Synthesis of Facial Amphiphile 3,7-Diamino-5α-cholestane Derivatives as a Molecular Receptor
Bulletin of the Korean Chemical Society (2009)
  • Md Wasi Ahmad
  • Young Mee Jung
  • Sharaf Nawaz Khan
  • Hong Seok Kim
Abstract

A series of facial amphiphiles 3,7-diaminocholestane were synthesized from 3,7-diketocholestane via 2 sequential reductive aminations and anion recognition was evaluated with acetate, chloride, bromide, fluoride and phosphate anions. The stereo-selective reductive amination protocol was utilized to synthesized facial amphiphiles afforded receptors in high yields. The molecular receptor 2 showed the highest binding constant with acetate in a 1:1 ratio.

Keywords
  • Facial amphiphile,
  • Anion receptor,
  • Reductive amination,
  • Aminosteroids,
  • Stereoselectivity
Publication Date
2009
Citation Information
Md Wasi Ahmad, Young Mee Jung, Sharaf Nawaz Khan and Hong Seok Kim. "Synthesis of Facial Amphiphile 3,7-Diamino-5α-cholestane Derivatives as a Molecular Receptor" Bulletin of the Korean Chemical Society Vol. 30 (2009)
Available at: http://0-works.bepress.com.library.simmons.edu/wasiahmad/1/