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Stereoselective synthesis of 3,7-diarylaminocholestanes by titanium-mediated reductive amination
Steroids (2014)
  • Md Wasi Ahmad
  • Hong Seok Kim
Abstract

An efficient method for the synthesis of aryl aminocholestanes, using a chlorotriisopropoxytitanium (IV)-mediated reductive amination reaction of 5a-cholestane-3,7-dione, is reported. A series of 3, 7-diarylaminocholestane derivatives were prepared according to this methodology in up to 98% yield. These compounds were primarily characterized by 1H NMR, 13C NMR, and mass spectrometry.

Keywords
  • Reductive amination,
  • Stereoselective reaction,
  • Chlorotriisopropoxytitanium(IV),
  • 3a,
  • 7a-Diarylaminocholestane,
  • Antimicrobial activity
Publication Date
2014
Citation Information
Md Wasi Ahmad and Hong Seok Kim. "Stereoselective synthesis of 3,7-diarylaminocholestanes by titanium-mediated reductive amination" Steroids Vol. 88 (2014)
Available at: http://0-works.bepress.com.library.simmons.edu/wasiahmad/12/